Ocular Bacterial Anti-Infectives
Anti-infectives are a vital part of the treatment of ocular bacterial infections that include endophthalmitis, keratitis, conjunctivitis, and
blepharitis. Ocular therapy differs from systemic therapy with the direct use of topical application to the ocular surface, subconjunctival injection, or the direct injection of anti-infectives into the intracameral chambers. Anti-infective susceptibility is interpreted using the systemic standards assuming that the anti-infective concentrations are greater in the ocular tissue than the blood serum. Using these concepts, this course will review the respective mechanisms of activity for different classes of anti-infectives for the treatment of Gram-positive and Gram-negative infections, and discuss the aspects for the development of new anti-infectives.
Please read the following papers:
Endophthalmitis
http://emedicine.medscape.com/article/1201134-overview
Keratitis
http://en.wikipedia.org/wiki/Keratitis
http://emedicine.medscape.com/article/798100-overview
conjunctivitis:
http://en.wikipedia.org/wiki/Conjunctivitis
“Lacrimal immune response” section only:
http://en.wikipedia.org/wiki/Ocular_immune_system
Toll-like receptors as an example of immune response to bacteria:
http://en.wikipedia.org/wiki/Toll-like_receptor
Overview common eye pathogens:
http://en.wikipedia.org/wiki/Staphylococcus_aureus
http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa
virulence factors
http://en.wikipedia.org/wiki/Virulence_factor
antibiotic resistance